DEFINITION
Subcutaneous administration introduces a drug into the fatty tissue beneath the skin. The drug is then absorbed slowly into the systemic circulation from the local depot, producing a smoother pharmacokinetic profile than intravenous administration.
Long-acting GLP-1 receptor agonists such as Semaglutide are administered subcutaneously once weekly, exploiting depot release together with intrinsic albumin binding to sustain plasma exposure.
WHY IT MATTERS
Subcutaneous depot absorption is the delivery route enabling once-weekly Semaglutide dosing.
RELATED
Compounds