DEFINITION
A lyophilised powder is the solid residue that remains after an aqueous solution of a peptide has been freeze-dried. It typically presents as a fluffy, porous cake or as a fine amorphous powder, and may include bulking or stabilising excipients such as mannitol or trehalose depending on the manufacturing process.
The porous structure resulting from ice-crystal sublimation provides a high surface area, which enables rapid and complete reconstitution when sterile diluent is added. Lyophilised powders are typically shipped and stored between –20 °C and 8 °C to maximise long-term stability.
WHY IT MATTERS
Every reconstitution calculation, storage decision and stability expectation for a research peptide starts from its lyophilised form.
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