DEFINITION
Gastric emptying is the rate at which food and liquid contents exit the stomach into the small intestine. It is a major determinant of postprandial glucose kinetics and of satiety signalling from gastric distension.
GLP-1 receptor activation slows gastric emptying via vagally-mediated pathways. This is a well-documented pharmacological effect of GLP-1 receptor agonists such as Semaglutide and contributes both to reduced postprandial glucose excursions and to increased satiety.
WHY IT MATTERS
Slowed gastric emptying is one of the principal peripheral pharmacological effects of GLP-1 receptor agonism.
RELATED
Compounds